Dopamine Function After Prenatal Ethanol Exposure

Abnormal dopamine neurotransmission is suggested to cause the attention and hyperactivity problems often observed in children with fetal alcohol effect/fetal alcohol syndrome (FAE/FAS). This study investigated how prenatal ethanol exposure influences the postnatal development of dopamine neurotransmission, how dopamine neurotransmission can be normalized by amphetamine-like stimulants, and more about the cellular mechanisms leading to these changes. The results of this study may lead to the development of more appropriate pharmacologic treatments for specific behavioral problems of FAE/FAS. Funded by a grant of $1,162,538 from NIAAA, 1999-2005.