Senior Research Scientist
Research Associate Professor, Pediatrics
Research Associate Professor, Psychology
The impact of parental prenatal and postnatal substance abuse on
developmental trajectories of risk and resilience from infancy to
Molnar | Eiden
Research on the effects of prenatal tobacco exposure on child health outcomes have established that children who have been prenatally exposed to tobacco are at a higher risk for a multitude of poor health outcomes, such as respiratory illnesses, hypertension, type II diabetes, obesity and certain types of cancer in all ages. However, we know little about the pathways by which prenatal tobacco exposure is associated with childhood health. This research is designed to determine whether salivary biomarkers can accurately assess oral immune system functioning in kindergarten-aged children, and will allow us to better understand the role of immune system functioning in linking prenatal tobacco exposure to later important child health outcomes. Funded by RIA's Howard T. Blane Director’s Award for Development of Innovative Research in the Addictions (BDAA), 2014-15.
The goal of this secondary data analysis project is to examine developmental sequelae of six etiological subgroups of low birthweight infants. This one-year study is funded by the Health Resources and Services Administration, U.S. Department of Health and Human Services. Xiaozhong Wen of the UB Department of Pediatrics is the Principal Investigator, with Leonard Epstein of the UB Department of Pediatrics and Rina Das Eiden as Co-Investigators.
Eiden | Leonard
Researchers will study the impact of early childhood risk and protection and parents’ alcohol problems on underage drinking and substance use in a prospective study spanning infancy to adolescence in order to help develop early interventions to address the issue.
This prospective study will examine developmental pathways to
substance use among adolescents with alcoholic fathers and a
matched control group. Participants were recruited and
assessed at several time points in early and middle
childhood. The study will examine the role of risk and
protective factors from early childhood in predicting to onset and
progression of substance use in adolescence. Kenneth
of RIA and Craig Colder, PhD, of the UB Dept. of
Psychology are Co-Investigators on the study. Award from NIAAA for
This project will examine the developmental risk and protective
factors associated with involvement in teen dating violence (TDV).
An additional wave of data will be collected from an existing
longitudinal sample of adolescent girls and boys, who are currently
in Grades 11-12. This sample of youth was originally recruited at
12 months of age, along with their parents, for an NIAAA-funded
study of the effects of parental alcoholism on child development
and Infant Development Study, Rina
Eiden, PI). The participants have been assessed at key
developmental points since 12 months of age, with the most recent
wave of data collection occurring at Grade 8. A dynamic cascade
model of development will be used to explore the progression from
early childhood (i.e., parental alcoholism and parenting behaviors)
and early adolescent (i.e. social competence, self-regulation,
substance use) risk factors to involvement in TDV during late
adolescence. Co-Investigators on the project are Dr. Rina
Eiden and Dr. Kenneth
Leonard. Funded by a grant of $798,396, awarded by the National Institute of
Cigarette smoking during pregnancy is a significant public health issue that can have profound effects on women’s health and the health of their developing fetus. Smoking among pregnant women is associated with high levels of negative affect, which plays a key role in both continuing to smoke and attempting to quit smoking. The smoking cessation treatment strategies that have demonstrated effectiveness in regular smokers have not translated into effective treatment strategies for pregnant women. Therefore, the goal of this project was to develop and test an affect regulation smoking cessation intervention for pregnant smokers, particularly low-income pregnant smokers for whom other treatments have been ineffective. In phase one of the project, Dr. Bradizza and colleagues developed an eight-session Affect Regulation Training intervention. In phase two, a randomized clinical trial was conducted to compare the Affect Regulation Training intervention with a control intervention. The trial assessed the impact on smoking cessation rates at the six-month post-quit date and changes in affect regulation skills and negative affect among pregnant smokers, thereby providing long-term health benefits for both the mothers and their children. Dr. Bradizza’s co-investigators included Drs. Rina Eiden, Paul Stasiewicz, and Dr. Thomas Brandon of the H. Lee Moffitt Cancer Center and the University of South Florida. Funded by a grant of $1,816,091 from NIDA and the Office of the Director, NIH, 2007-2012.
Colder | Schuetze
This study will examine the impact of prenatal exposure to cocaine and other substances and associated environmental risks on the development of children’s ability to regulate physiology and behavior in response to stress from birth to middle childhood and social competence in the school setting.
The purpose of this study is to investigate the impact of prenatal cocaine and other substance exposure on developmental trajectories for self-regulation from toddler to kindergarten age. Self-regulation is defined as the emergence of impulse control, compliance, and internalization of rules of conduct. As the children in the study begin kindergarten, assessments will also include children’s adjustment to the school setting and classroom behavior. In addition to maternal substance use, other risk factors often associated with maternal substance use such as poor infant growth, maternal depression, anxiety, and anger/hostility, and caregiving instability will be measured at each time point, and considered as mediators or moderators of child outcomes. This is a collaborative project among Dr. Rina Eiden, RIA, and Drs. Craig Colder, University at Buffalo, and Pamela Schuetze, Buffalo State College. Other significant contributors are Drs. Claire Coles, Emory University, and Phillip Zeskind, Carolinas Medical Center. Funded by a grant of $3,201,187 from NIDA, 2007-2014.
Colder | Homish | Schuetze
This study is investigating the impact of prenatal and postnatal exposure to cigarette smoke and associated environmental risks on the development of children’s physiological, emotional and behavioral regulation, reactivity to stress, and social competence from birth to kindergarten age.
In this continuation of a longitudinal, multi-method study, Principal Investigator Dr. Rina Eiden is investigating the impact of prenatal and passive exposure to cigarette smoke on the development of self-regulation and social competence upon entry into kindergarten. The study will also examine developmental trajectories of reactivity and regulation using behavioral and biological indices among cigarette exposed and non-exposed children from birth to early school years. Additional goals of the study are to eamine if associations between cigarette exposure and children's self-regulation and social competence may be mediated by developmental trajectories of reactivity and regulation in the infant/toddler years; and to examine if these associations may be moderated by infant perinatal risks, maternal risks (psychopathology, parenting), or cumulative environmental risk. This study addresses several gaps in the literature including examination of multiple levels of self-regulation, long-term developmental pathways associated with cigarette exposure, and consideration of key mediators and moderators of these pathways. Understanding developmental trajectories will inform the timing of prevention/intervention efforts. Understanding mediating processes that predict outcomes, or may act to increase risk or promote resilience will inform the content of interventions. Co-investigators on the study include Pamela Schuetze, Buffalo State College, Craig Colder, UB Department of Psychology, and Gregory Homish, UB School of Public Health and Health Professions. Funded by a grant of $2,988,951 from NIDA, 2006-2017.
This longitudinal study examines the role of parents’ alcohol problems on developmental trajectories of children’s self-regulation, peer relationships, and cognitive development using a transactional approach that considers multiple influences on parenting and child development. These include factors associated with parents’ alcohol problems such as depression and antisocial behavior as well as contextual factors such as marital aggression, life stress, and support. From 1994-2004, families were assessed when children were 12, 18, 24, 36 months of age, at 4 years, and upon entry into kindergarten. In infancy, the primary focus was on examining the parent-child relationship. In the toddler and preschool period, measures of children’s emerging self-regulatory abilities were added. In school age, the focus shifted to include classroom behavior and peer relationships, while continuing to assess the development of self-regulation. At every age, the quality of parent-child interactions were assessed using observational measures. Parents’ psychological problems, relationships with partners, stress, and support were also assessed at each age. In this continuation, families are assessed when children are in fourth and sixth grade. Assessments focus on peer relationships, self-regulation, cognitions about substance use, parenting, and family processes. In addition to Drs. Eiden and Leonard, the continuation study team includes Drs. Craig Colder, UB Department of Psychology; Kerry Grohman, VA Western New York Healthcare System; and Ellen Edwards, Capella University. Funded by a grant of $3,342,981 from NIAAA, 2005-2012.
Colder | Eiden | Lengua | Hawk | Read | Wieczorek
In this longitudinal study, Principal Investigator Dr. Craig Colder of UB’s Department of Psychology examined how shifts in appetitive motivation converge with community and peer contexts to influence both implicit and explicit beliefs supportive of substance use. Starting from developmental-ecological theory that posits the initiation of substance use in childhood and adolescence is a function of reciprocal and interacting influences between individuals and their socio-environmental context, a sample of 10-12 year old children were assessed across three waves. This allowed for the examination of how changes in these constructs presaged substance use. Child motivational profiles based on approach, inhibition and self-regulation were assessed using laboratory tasks, physiological indicators and parent reports. Multiple methods were used to assess beliefs about substance use, and peer and community context. This research has the potential to provide important direction for how the content of substance use preventive interventions could be tailored for specific populations and to target relevant etiological processes for maximal effectiveness. His co-investigators included RIA’s Dr. Rina Eiden and Dr. Liliana Lengua of the University of Washington, Drs. Larry Hawk and Jennifer Read of UB's Department of Psychology, and Dr. William Wieczorek of Buffalo State College. Funded by NIDA to Dr. Colder, subaccount to RIA, 2006-2011.