Genetic and Behavioral Dissection of Inhibitory Control

Zhuang | Richards

This study investigated biochemical changes underlying impaired inhibitory control in dopamine transporter expression (DAT knockdown) mice. Researchers tested the hypothesis that impaired postsynaptic dopamine D2 receptor function underlies impaired inhibitory control using a pharmacological rescue approach. They also tested the hypothesis that impaired D2 receptor function underlies impaired inhibitory control using mice that lack or have reduced postsynaptic D2 receptors. Funded by NIMH to Dr. Xiaoxi Zhuang, University of Chicago’s Neurobiology/Pharmacology/Physiology Department; subaward to Dr. Jerry Richards, RIA, 2003-2008.