In this study, Dr. Paul Stasiewicz and colleagues developed and piloted a clinical intervention that addresses the problem of negative affect as it relates to alcohol use and alcohol relapse. Currently, negative affect is a component of nearly half of all relapses to alcohol use among men and women in treatment, however no well-developed, empirically-tested, efficacious treatments specifically address the impact of negative affect on relapse. This project will assist individuals in treatment to regulate and cope with negative affective episodes that threaten relapse to alcohol use. Phase one will develop a 12-session treatment manual for Affect Regulation Training (ART) delivered concurrently with a standard 12-session Treatment as Usual (TAU). Phase two will encompass a pilot study of outcomes for individuals participating in ART and TAU compared to individuals who receive TAU and a Health and Lifestyle Supplement (HLS). The long-term objective of this line of research is to make a brief, effective affect regulation intervention available to clinicians to enhance treatments for alcohol dependence. Dr. Stasiewicz’s colleagues on the project included Drs. Clara Bradizza, RIA, Scott Coffey, University of Mississippi’s Department of Psychiatry, and Suzy Bird Gulliver, Boston University’s Department of Psychiatry. Funded by a grant of $1,937,729 from NIAAA, 2005-2011.