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Integrated GWAS of Complex Behavioral and Gene Expression Traits in Outbred Rats

Richards | Lucke | Meyer
Researchers will explore the link between addiction and various behaviors, such as response to novelty, sustained attention, reaction time and preferences for rewards. 

This project is part of a multi-site center examining the genetic basis of behavioral traits related to drug abuse.  This component will study animal models of five psychological traits (sensation seeking, inattention, impulsivity, habituation, and the attribution of incentive salience) thought to underlie behavioral regulation and to be related to drug abuse. Some or all of these psychological traits are thought to predispose individuals to drug addiction. The relationship of these traits to each other and the degree to which the traits, both individually and together, predict cocaine cue preference will be determined.  The genetic basis of these traits will be then be examined through the use of a genome wide association study (GWAS) at the University of California at San Diego. The results of the analysis will provide valuable information regarding how well the psychological traits predict cocaine cue preference and the genetic influences on these traits.

Principal Investigator
Jerry Richards, PhD
Research Institute on Addictions

Co-Investigators
Joseph Lucke, PhD
Research Institute on Addictions

Paul Meyer, PhD
Department of Psychology
University at Buffalo

Funding Agency
University of California, San Diego
National Institute on Drug Abuse (NIDA)

Grant Number
P50-DA037844

Dates
2014-2019