Protocol Information

If you are interested in learning more about this study, please call or email the contact person below

Title A multicenter, randomized, double-blind, double-dummy, parallel group, active-controlled, forced-titration, 12-week comparison of combined angiotensin-neprilysin inhibition with sacubitril and valsartan versus enalapril on changes in central aortic stiffness in patients with heart failure and reduced ejection fraction (HFrEF)
Description Study comparing Sacubitril and Valsartan versus Enalapril on Changes in Central Aortic Stiffness in Patients With Heart Failure and Reduced Ejection Fraction

Study visits will be at Erie County Medical Center in Buffalo

If you are interested in this study, please contact the coordinator below
Objective A study of the effects of sacubitril and valsartan vs. enalapril on aortic
stiffness in patients with mild to moderate heart failure and reduced
pumping ability.

Keywords: Heart Failure
Reduced Ejection Fraction
Central Aortic Stiffness
Vascular
Heart Disease
Principal Investigator IZZO, JOSEPH
Age Group Adult
Drugs Involved
Clinical Trials.gov http://www.clinicaltrials.gov/ct2/show/NCT02874794/
Status Open
Key Eligibility History of Hypertension (HTN)
Heart failure
Reduced cardiac ejection fraction
Disease Group Heart Diseases
Treatment LCZ696 (sacubitril/valsartan)
Enalapril
Contact KELLEY CAROZZOLO
716-898-5653
kjc28@buffalo.edu