Environmental Exposures, Genomes, and Health
Vision
The Environmental Exposures, Genomes, and Health focus area will stimulate integrated, multidisciplinary research and education at UB to conduct innovative, cutting edge environmental research.
This focus area will address the grand challenge to better characterize environmental exposures, and understand the impact of environmental stressors and genomes on health across generations, with the ultimate goal to promote health and prevent disease, locally, nationally, and globally.
Background and Rational
Historically, Western New York is an important area with diverse environmental health challenges that are a legacy of chemical companies that located here in part because of plentiful and cheap electrical power and fresh water. Multiple superfund sites including the Love Canal, Hooker Chemical and Plastics Corp., Waste Management Inc. are located here. Nearly 800 hazardous waste sites are located in Erie, Niagara and Cattaraugus counties, and the majority of them are a potential threat to the Great Lakes. In more recent years, environmental health issues, ranging from Great Lakes contaminants to air pollution associated with high traffic at the Peace Bridge and the Tonawanda Coke facility have gained attention locally and nationally. Although air quality in western New York has improved in more recent years, due to the closure of Bethlehem Steel in Lackawanna, and the recent reductions in benzene emissions from Tonawanda Coke, there remains a great need to not only characterize current environmental exposures and but to reconstruct historical air pollution data in western New York since cumulative past environmental exposures from multiple sources remain a potential concern for the health of current and future generations.
Advance, innovative approaches are needed to better characterize historical and current environmental exposures and resulting health outcomes across the lifespan. A related challenge is to utilized recent advances in human genetics, the microbiome and the big data available from digital health records to evaluate gene-environment interactions or the impact of both environmental exposures and genomes on health outcomes across multiple generations.
Environmental stressors are not limited to chemical toxins, but also include biological (bacterial, viral; microbiome), and physical stressors, such as radiation and the impacts of climate change. Efforts to understand the impact of chemical exposures and gene-environment interaction must also consider these other environmental stressors which are a public health concern locally, nationally, and globally. Ultimately, the health of the planet depends on mitigating the potential impacts of chemical, biological and physical stressors on human health. What is protective of human health is generally also protective for our planet.
Focus Area Lead
Lina Mu
Director, Office of Global Health Initiatives, Associate Professor
Department of Epidemiology and Environmental Health
Professor Mu's Biography
Dr. Lina Mu joined the department of Epidemiology and Environmental Health in June 2008 as an Assistant Professor, and was named Associate Professor in August 2013. Her areas of research include Environmental Epidemiology, Air Pollution, Water Pollution, Cancer Molecular Epidemiology (primarily lung cancer, breast cancer, and upper-GI cancers,) Gene-Environment Interaction, and Cancer Survival.
Dr. Mu received an MD from Shanxi Medical University in 1995, and her PhD in Epidemiology and Health Statistics from Fudan University in 2002. She is a member of the American Association for Cancer Research, the International Epidemiologic Association, the International Society for Environmental Epidemiology, and the Molecular Epidemiology Working Group.
Grand Challenge
“Characterizing and Mitigating the Health Effects of Environmental and Occupational Exposures Across the Lifespan”
The grand challenge will address the important, unmet need to understand the impact of a life-time of environmental stressors (chemical, biological, physical) and genomes on health outcomes across multiple generations.
There is interest in the following activities:
- Develop and Utilize New approaches to assess exposures across the life span (pollutants in air, water, soil, food)
- Collect and model historical data on air pollution, waste sites and other industrial and municipal discharges in WNY
- Utilize geographic information system (GIS) analysis, senor technology, chemical analysis, and modelling approaches to estimate past and current exposures.
- Collect and bank human bio-specimens (urine, blood, saliva, etc) which can be used to provide sensitive and specific Human Biomarkers of Exposure, Effect and Susceptibility to chemicals of interest [such as, Pesticides, Persistent Organic Pollutants (PCBs, PBDEs, Dioxins, Furans, etc.), metals (arsenic, manganese), polycyclic aromatic hydrocarbons (PAHs), benzene].
- Future efforts in exposure science will expand to include the emerging field of the exposome. The exposome encompasses the totality of human environmental (i.e. non-genetic) exposures from conception onwards, complementing the genome Wild (2005, 2012) described three overlapping domains within the exposome: 1) a general external environment including the urban environment, climate factors, social capital, stress, 2) a specific external environment with specific contaminants, diet, physical activity, tobacco, infections, etc., and 3) an internal environment to include internal biological factors such as metabolic factors, gut microflora, inflammation, oxidative stress.
- To determine the impact of environmental stressors on the human genome and microbiome and together, their impact on health outcomes.
- To mitigating the health effects of environmental and occupational exposures.
Why UB?
A RENEW Focus in Environmental Exposures, Genomes, and Health Environmental Health requires collaborative multidisciplinary approaches to address key research questions.
A number of UB faculty have actively participated in developing a strategic plan for this renew focus area. A total of 43 faculty from 14 Departments, representing the Schools of Public Health a Health Professions, Medicine and Biomedical Sciences, Nursing, Arts and Sciences, Engineering and Applied Sciences, Architecture and Planning and Social Work have expressed an interest in the RENEW Focus in Environmental Exposures, Genomes, and Health. Faculty with backgrounds in epidemiology and environmental health, toxicology, chemistry, engineering, geography, biology, public health, medicine, nursing, urban planning, and communications are part of this focus area.
UB has additional unique strengths with centers and communities of excellence which directly support Environmental Health research and education, including:
- National Center for Geographic Information Analysis (NCGIA)
- Buffalo Institute for Genomics and Data Analytics (BIG)
- Community of Excellence (COE) in the Genome, the Environment, and the Microbiome (GEM)
- Community of Excellence (COE) in Global Health Equity (GHE)
- Center of Excellence in Bioinformatics and Life Sciences
- Institute of Healthcare Informatics
- Atlantic Occupational Safety and Health Administration (OSHA) Training Center
- Environmental Analytical Chemistry Supporting Human Exposure Assessment (North Campus: Analytical Environmental Chemistry; and South Campus: Toxicology Research Center Analytical Facility)
- Epidemiology and Environmental Health
- Pharmacology and Toxicology
- Biological Sciences
· Civil and Environmental Engineering
- Nursing
- Community Health and Health Behavior
The combination of 1) geographic location with numerous environmental concerns, 2) a strong interdisciplinary faculty, and 3) specialized research centers and communities of excellence sets UB apart from other Institutions with Environmental Health Centers.
Environmental Health at UB is poised to become a leader in the areas of Exposure Science and Gene-Environment Interactions by focusing our efforts to better understand the impacts of a life-time of environmental stressors (chemical, biological, physical) and genomes on health outcomes across multiple generations.
