Paez Research Overview

Our research program focuses on brain development, studying the development of the oligodendroglial and astroglial cell lineages in the central nervous system in normal, mutant and transgenic mice. The primary focus in the laboratory is on ion channels that regulate specification, migration and differentiation of these glial cells. The oligodendrocyte generates CNS myelin, which is essential for normal nervous system function. Thus, investigating the regulatory and signaling mechanisms that control its differentiation and the production of myelin is relevant to our understanding of brain development and of adult pathologies such as multiple sclerosis. Astrocytes are the most abundant cell of the human brain. They perform many functions, including biochemical support of endothelial cells that form the blood brain barrier, provision of nutrients to the nervous tissue and a role in the repair and scarring process of the brain and spinal cord following traumatic injuries. Therefore, understanding the role of ion channels on astrocyte development and function could lead to novel approaches to intervene in neurodegenerative diseases and brain injuries in which inflammation and astrogliosis play a detrimental role.

Faculty and Staff

Dr. Pablo M. Paez

Associate Professor of Pharmacology & Toxicology

Dr. Pablo M. Paez is a Principal Investigator of the Hunter James Kelly Research Institute and Assistant Professor in Pharmacology and Toxicology in the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo...

photo of Dr. Pablo M. Paez

Veronica Cheli

Senior Research Scientist, HJKRI, Paez Lab

  • 2013-present Senior Research Scientist Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences University at Buffalo, The State University of New York
  • 2011-2012 Staff Research Associated Intellectual and Developmental Disabilities Research Center David Geffen School of Medicine University of California at Los Angeles
  • 2006-2011 Postdoctoral Scholar Department of Human Genetics, David Geffen School of Medicine University of California at Los Angeles
  • 2000-2006 Academic Tutor/Teaching Assistant Laboratory of Neuroscience, Department of Cell Biology School of Pharmacy and Biochemistry University of Buenos Aires, Argentina.
  • 2000-2005 Research Assistant and Instructor Laboratory of Neuroscience, Department of Cell Biology School of Pharmacy and Biochemistry University of Buenos Aires, Argentina.
photo of Veronica Cheli

Vilma Spreuer

Research Technician, HJKRI, Paez Lab

  • 2013-present Research Technician Step III Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences University at Buffalo, The State University of New York
  • 1992-2012 Staff Research Associated Step II Intellectual and Developmental Disabilities Research Center David Geffen School of Medicine University of California at Los Angeles
photo of Vilma Spreuer

Diara Santiago Gonzalez

Postdoctoral Associate, HJKRI, Paez Lab

  • 2008 - 2012: Bachelor Degree in Chemistry, University of Puerto Rico, Rio Piedras Campus.
  • 2012 - 2017: PhD Student at the University at Buffalo, NY, USA, Jacobs School of Medicine and Biomedical Sciences, Department of Pharmacology and Toxicology, Hunter James Kelly Research Institute.
  • 2017 - present: Postdoctoral Associate at the University at Buffalo, NY, USA, Jacobs School of Medicine and Biomedical Sciences, Department of Pharmacology and Toxicology, Hunter James Kelly Research Institute.
photo of Diara Santiago Gonzalez

Norma Zamora

PhD student, HJKRI, Paez Lab

  • 2011 – 2013: BA Psychology, California State University, San Bernardino.
  • 2015 – Present: PhD Student in the Department of Pharmacology and Toxicology, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences.
photo of Norma Zamora

Students

photo of Tensing Lama

Tensing Lama, Master student, College of Art and Sciences

photo of Rensheng Wan

Rensheng Wan, Master Student, Pharmacology and Toxicology

photo of Shaina Rosenblum

Shaina Rosenblum, Master Student, Neuroscience