Basic research is based on a multi-disciplinary approach to understand how myelin is formed, how it is damaged in disease, and how it may be repaired. In particular, HJKRI will study disease mechanisms of Krabbe Disease in order to formulate therapies. HJKRI strives to generate information that will promote effective treatment strategies not only for children with leukodystrophies, but also patients with Multiple Sclerosis, stroke, neuropathies and other diseases in which myelin is damaged.

We are studying the cell-autonomous and non-cell-autonomous mechanisms of axon degeneration, a process akin to programmed cell death.
We seek to understand how cell-cell and cell-extracellular matrix interactions contribute to cell shape and polarity within a developing tissue.
During the past five years Dr. Paez have found new and novel functions of voltage and store-operated Ca ++ channels as modulators of intracellular Ca ++ levels in oligodendrocytes.
Our research goal is to understand the transcriptional regulatory network governing the differentiation of oligodendrocytes and central nervous system myelination.
The Wrabetz Laboratory is interested in the molecular genetics of myelination, studied primarily in transgenic mice.