Basic research is based on a multi-disciplinary approach to understand how myelin is formed, how it is damaged in disease, and how it may be repaired. In particular, HJKRI will study disease mechanisms of Krabbe Disease in order to formulate therapies. HJKRI strives to generate information that will promote effective treatment strategies not only for children with leukodystrophies, but also patients with Multiple Sclerosis, stroke, neuropathies and other diseases in which myelin is damaged.