Paez Research Overview

Our research program focuses on brain development, studying the development of the oligodendroglial and astroglial cell lineages in the central nervous system in normal, mutant and transgenic mice. The primary focus in the laboratory is on ion channels that regulate specification, migration and differentiation of these glial cells. The oligodendrocyte generates CNS myelin, which is essential for normal nervous system function. Thus, investigating the regulatory and signaling mechanisms that control its differentiation and the production of myelin is relevant to our understanding of brain development and of adult pathologies such as multiple sclerosis. Astrocytes are the most abundant cell of the human brain. They perform many functions, including biochemical support of endothelial cells that form the blood brain barrier, provision of nutrients to the nervous tissue and a role in the repair and scarring process of the brain and spinal cord following traumatic injuries. Therefore, understanding the role of ion channels on astrocyte development and function could lead to novel approaches to intervene in neurodegenerative diseases and brain injuries in which inflammation and astrogliosis play a detrimental role.

 

Faculty and Staff

Dr. Pablo M. Paez 
Assistant Professor of Pharmacology & Toxicology

Dr. Pablo M. Paez is a Principal Investigator of the Hunter James Kelly Research Institute and Assistant Professor in Pharmacology and Toxicology in the School of Medicine and Biomedical Sciences, University at Buffalo...

Veronica Cheli

Senior Research Scientist, HJKRI, Paez Lab

  • 2013-present Senior Research Scientist Hunter James Kelly Research Institute School of Medicine and Biomedical Sciences University at Buffalo, The State University of New York
  • 2011-2012 Staff Research Associated Intellectual and Developmental Disabilities Research Center David Geffen School of Medicine University of California at Los Angeles
  • 2006-2011 Postdoctoral Scholar Department of Human Genetics, David Geffen School of Medicine University of California at Los Angeles
  • 2000-2006 Academic Tutor/Teaching Assistant Laboratory of Neuroscience, Department of Cell Biology School of Pharmacy and Biochemistry University of Buenos Aires, Argentina.
  • 2000-2005 Research Assistant and Instructor Laboratory of Neuroscience, Department of Cell Biology School of Pharmacy and Biochemistry University of Buenos Aires, Argentina.

Vilma Spreuer

Research Technician, HJKRI, Paez Lab

  • 2013-present Research Technician Step III Hunter James Kelly Research Institute School of Medicine and Biomedical Sciences University at Buffalo, The State University of New York
  • 1992-2012 Staff Research Associated Step II Intellectual and Developmental Disabilities Research Center David Geffen School of Medicine University of California at Los Angeles

  

Diara Santiago Gonzalez

PhD student, HJKRI, Paez Lab

  • 2008 - 2012: Bachelor Degree in Chemistry, University of Puerto Rico, Rio Piedras Campus.
  • 2012 - present: PhD Student at the University at Buffalo, NY, USA, School of Medicine and Biomedical Sciences, Department of Pharmacology and Toxicology, Hunter James Kelly Research Institute.

Norma Zamora

PhD student, HJKRI, Paez Lab

  • 2011 – 2013: BA Psychology, California State University, San Bernardino.
  • 2015 – Present: PhD Student in the Department of Pharmacology and Toxicology, University at Buffalo, School of Medicine and Biomedical Sciences.

   

Students

Tensing Lama, Master student, College of Art and Sciences