Students will participate in research exploring immunotherapy for infectious disease toward the goal of eradicating pathogens and increasing patient benefits.
I am developing a new therapy in which the effects of these drugs are combined with augmenting the actions of the innate immune system, to act synergistically to eradicate pathogens which could potentially reduce the drug dosage required, shorten the treatment duration, mitigate dose‐dependent toxicity, and reduce the emergence of drug resistance. This delivery vehicle is a nanoparticle with a macrophage‐specific, immune‐stimulatory ligand on the surface. This nanoparticle will deliver TB and/or HIV drugs specifically to macrophage while concomitantly inducing the production of cytokines and reactive oxygen/nitrogen species within the macrophage, with the goal of intracellular pathogen clearance. We found that we could target and activate macrophage using beta glucan on the surface of a nanoparticle. Furthermore we found that would could increase intracellular uptake within macrophage of TB and HIV drugs. This approach will broaden our scientific knowledge of HIV and/or TB disease therapies and, by combining targeted drug delivery with immune augmentation, create new approaches that will facilitate reducing individual drug doses, reduce systemic drug toxicity and reduce the development of drug resistance.
The specific outcomes of this project will be identified by the faculty mentor at the beginning of your collaboration.
|Length of commitment||To be determined by student/mentor|
|Start time||Fall, Spring, Summer|
|Level of collaboration||To be determined by student/mentor|
|Who is eligible||Students with basic laboratory skills and the ability to work independently|
Students participating in this project might be interested in and eligible for the Goldwater Scholarship and the National Science Foundation Graduate Research Fellowship. Connect with the Office of Fellowships and Scholarships to learn more.
The specific preparation activities for this project will be customized through discussions between you and your project mentor. Please be sure to ask them for the instructions to complete the required preparation activities.