2015-2016 Pilot Studies Awarded

Awardees BTC Institution Title of Project

Mark Ehrensberger, PhD
Anthony Campagnari, PhD

Jacobs School of Medicine and Biomedical Sciences

A Novel Electrical Stimulation Technology Changing the Paradigm for the Treatment of Orthopedic-related Infections
Qiaoqiang Gan, PhD
Yun Wu, PhD
Daniel Gaile, PhD

School of Engineering and Applied Sciences

School of Public Health and Health Professions

Highly Sensitive and Portable Surface Plasmon Resonance System for Lung Cancer Early Detection
Andrew Gulick, PhD
Thomas Russo, MD

Hauptman-Woodward Medical Research Institute

Jacobs School of Medicine and Biomedical Sciences

Development of High-throughput Assay for Inhibitors of Aerobactin Synthesis

Rachael Hageman Blair, PhD
Jeffrey Miecznikowski, PhD
Kunle Odunsi, PhD
Thomas Szyperski, PhD

School of Public Health and Health Professions

Roswell Park Comprehensive Cancer Center

College of Arts and Sciences

Multi-class Modeling of Metabonomics Data for the Detection of Early Stage Ovarian Cancer

Jill Kramer, DDS, PhD
Daniel Gaile, PhD

School of Dental Medicine

School of Public Health and Health Professions

Analysis of the Source and Significance of IgM in Sjögren’s Syndome
Xuefeng Ren, MD, PhD
Daniel Gaile, PhD
Jie Wang, PhD

School of Public Health and Health Professions

Jacobs School of Medicine and Biomedical Sciences

Inheritable Epigenetic (DNA methylation) Biomarkers and Actions of Arsenic Exposure in its Carcinogenic Activity
Fraser Sim
Jacobs School of Medicine and Biomedical Sciences
Inducing Myelin Repair by Antagonism of Muscarinic Receptor Type-3
Xiaozhong Wen
Leonard Epstein
Stephen Higgins
Rina Eiden
Faye Justicia-Linde
Youfa Wang

Jacobs School of Medicine and Biomedical Sciences

Research Institute on Addictions

School of Public Health and Health Professions

Pilot Study on Pediatric Obesity Prevention by Maternal Smoking Cessation in Pregnancy and Lactation

Publications

1.    Bailey DC, Alexander E, Rice MR, Drake EJ, Mydy LS, Aldrich CC, Gulick AM. Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae. J Biol Chem. 2018 May 18;293(20):7841-7852. PMCID: PMC5961048

2.    Bailey DC, Buckley BP, Chernov MV, Gulick AM. Development of a High-Throughput Biochemical Assay to Screen for Inhibitors of Aerobactin Synthetase IucA. SLAS Discov. 2018 Dec;23(10):1070-1082. PMCID: PMC6246805

3.    Bailey DC, Drake EJ, Grant TD, Gulick AM. Structural and Functional Characterization of Aerobactin Synthetase IucA from a Hypervirulent Pathotype of Klebsiella pneumoniae. Biochemistry. 2016 Jun 28;55(25):3559-70. PMCID: PMC4928626

4.    Canty M, Luke-Marshall N, Campagnari A, Ehrensberger M. Cathodic voltage-controlled electrical stimulation of titanium for prevention of methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii biofilm infections. Acta Biomater. 2017 Jan 15;48:451-460. PMID: 27890730

5.    Guo X, Chen X, Wang J, Liu Z, Gaile D, Wu H, Yu G, Mao G, Yang Z, Di Z, Guo X, Cao L, Chang P, Kang B, Chen J, Gao W, Ren X. Multi-generational impacts of arsenic exposure on genome-wide DNA methylation and the implications for arsenic-induced skin lesions. Environ Int. 2018 Jul 4;119:250-263. PMCID: PMC6143427

6.    Liu C, Zeng X, An Z, Yang Y, Eisenbaum M, Gu X, Dy GK, Reid ME, Gan Q, Wu Y. Sensitive Detection of Exosomal Proteins via a Compact Surface Plasmon Resonance Biosensor for Cancer Diagnosis. ACS Sens. 2018 Aug 24;3(8):1471-1479. PMID: 30019892

7.    Russo TA, Gulick AM. Aerobactin Synthesis Proteins as Antivirulence Targets in Hypervirulent Klebsiella pneumoniae. ACS Infect Dis. 2019 Jul 12;5(7):1052-1054. PMCID: PMC6625901

8.    Welliver RR, Polanco JJ, Seidman RA, Sinha AK, O’Bara MA, Khaku ZM, Santiago González DA, Nishiyama A, Wess J, Feltri ML, Paez PM, Sim FJ. Muscarinic receptor M3R signaling prevents efficient remyelination by human and mouse oligodendrocyte progenitor cells. J Neurosci. 2018 Jun 29. pii:1862-17. PMCID: PMC6070663

9.    Wen X, Eiden RD, Justicia-Linde FE, Wang Y, Higgins ST, Kong KK, Shittu A, Perkins JM, Esadah P, Mautner T, Epstein LH. Reducing fetal origins of childhood obesity through maternal smoking cessation during pregnancy: an intervention study. Int J Obes (Lond). 2018 Dec 5. PMID: 30518822

10.    Wen X, Eiden RD, Justicia-Linde FE, Wang Y, Higgins ST, Thor N, Haghdel A, Peters AR, Epstein LH. A multicomponent behavioral intervention for smoking cessation during pregnancy: a non-concurrent multiple baseline design. Trans Behav Med. 2018 Apr 10. PMCID: PMC6610210

11.  Zeng X, Yang Y, Zhang N, Ji D, Gu X, Jornet J, Wu Y, Gan Q. Plasmonic Interferometer Array Biochip as a New Mobile Medical Device for Cancer Detection. IEEE J Sel Top Quantum Electron. 2019 Jan-Feb;25(1). pii: 7201707. PMCID: PMC6456910