The University at Buffalo Clinical and Translational Science Institute (CTSI) provides support for pilot projects encouraging imaging translational research. The CTSI Center for Biomedical Imaging (CBI) is seeking to fund innovative pilot imaging studies. Projects must:
Projects will be given preference if they:
*Funding of any and all UB CTSI pilot study awards will be dependent upon allocation of funds to the pilot study program.
Research that uses imaging to address health disparities can be implemented across all levels of analysis with imaging correlates, including examples such as understanding genetic or epigenetic effects on health disparities in structural or functional imaging outcomes; through biological and neurobiological influences on health disparities, individual differences in response to drugs that may explain differential health benefits to new or commonly used pharmacological interventions; or developing unique programs that address health disparities for underrepresented populations in Western New York, including T3 and T4 translational research projects, is invited for this pilot seed grant submission.
In addition, imaging proposals that will advance the ways in which creativity and innovation can be stimulated, fostered, and augmented in the design and conduct of translational imaging-related research will be entertained.
No clinical trials beyond phase IIA will be supported by the program.
These pilot imaging studies will be partially supported by the Clinical and Translational Science Award (CTSA) with the CBI providing up to 100 imaging hours on 9.4T and PET/CT scanners at “at no cost,” with intended durations of one year.
Support for pilot projects will be based on available scanning time and human resources at the 9.4T and PET/CT scanners. The CBI anticipates that it will support three pilot projects with intended durations of one year.
You must 1) be a full-time faculty member at UB or an affiliated Buffalo Translational Consortium institution; 2) agree, if called upon, to serve as a reviewer of other proposals submitted for pilot studies funding either by UB faculty or in exchange of reviews with other CTSA institutions; and 3) must report grant progress, publications and grants resulting from the pilot study on a quarterly basis to the CBI during and for up to three years after conclusion of the project*.
*Any publications resulting from the pilot study, including those that arise beyond three years, must cite the CTSA.
Applying for pilot studies funding involves a two-tiered process:
There is a two-page limit for LOIs. First page should provide 1) succinct title for the proposal, and 2) list of names/degrees and institutional affiliations of all investigators involved in the project. Second page should provide a succinct abstract of the proposal, summarizing a) what the project entails; b) a clear statement of the translational significance of the project, the expected outcomes, and the potential application of those outcomes; and 3) how the pilot study will lead to substantive extramural funding (e.g., an NIH R01, R21, or comparable grant).
FORMAT: LOIs should be submitted as a single PDF in Arial 11-point font, single-spaced text, 0.5-inch margins. Submissions must be emailed to CTSA-Pilot-Studies@buffalo.edu.
DUE DATE FOR SUBMISSION: February 1, 2022 by 9:00 a.m.
All applicants will be notified by March 1, 2022, with a decision as to whether or not their proposal has been selected to move forward to the second tier of the application process
Invited applicants should use the following template.
a. Project title
b. Names/degrees of all project investigators and their institutional affiliations
c. Abstract (300 word max)
d. Five key words relevant to your research topic
e. Two sentences that describe your project for a general scientific audience
f. Indication whether the project involves human and/or animal subject research
Pages 2-5 (4-page limit):
a. Specific aims
b. Background and significance of the project, including the clinical-translational relevance and potential impact on the field
c. Brief overview of approach
d. Study timeline with specific milestones to be accomplished
e. Role of pilot study in securing extramural funding for a larger, forward-going project
f. Brief explanation why the project meets the goals of the CTSI Imaging Pilot Study Program
FORMAT: Full proposals should be submitted as a single PDF in Arial 11-point font, single-spaced text, 0.5-inch margins. Proposals must be emailed to CTSA-Pilot-Studies@buffalo.edu.
DUE DATE: April 30, 2022, by 9:00 a.m.
All applicants will be notified on June 1, 2022, with a decision as to whether or not their proposal has been selected for funding.
REQUIREMENT: For proposals involving human subjects, the Principal Investigator is to register the study with Central Study Registration (CSR). To begin the CSR process, a proposal document (at minimum) is required. For any questions regarding CSR registration, please contact the CTSI Clinical Research Facilitators (829-4357).
*It is recommended that PIs from Roswell Park Comprehensive Cancer Center follow a similar process while utilizing the RPCCC Click and IRB.
Applications will be rated using the following criteria.
a. Scientific merit and innovation
b. Clinical significance and translational impact on the field
c. Potential for securing extramural funding
d. Realistic milestones and feasibility of completion within one year
e. Rationale and utilization of the “at no cost” scanning hours
The reviews of the proposals will be conducted by:
a. The CBI technical and faculty personnel to ensure feasibility of the proposed study
b. Independent imaging core steering committee
c. External reviewers