Panayotis (Peter) K. Thanos, PhD

Jaye L. Derrick, PhD.

Senior Research Scientist

Behavioral Neuropharmacology

Faculty, Neuroscience 

Department of Pharmacology and Toxicology
Jacobs School of Medicine and Biomedical Sciences

Contact Information

1021 Main Street
Buffalo, NY  14203-1016
Phone: (716) 881-7520


Primary Research Areas

The role of the mesolimbic dopamine circuit in addictive disorders with a focus on drug abuse, alcoholism and obesity

Research Publications Expertise

Representative and Recent Publications

Thanos, P.K., Kim, R., Delis, F., Ananth, M., Chachati, G., Rocco, M.J., Masad, I., Muniz, J.A., Grant, S.C., Gold, M.S., Cadet, J.L., & Volkow, N.D. (2016). Chronic methamphetamine effects on brain structure and function in rats. PLoS One, 11(6), e0155457.
PMID: 27275601 PMCID: PMC4898739 DOI: 10.1371/journal.pone.0155457

Thanos, P.K., Clavin, B.H., Hamilton, J., O'Rourke, J.R., Maher, T., Koumas, C., Miao, E., Lankop, J., Elhage, A., Haj-Dahmane, S., Deutsch, D., & Kaczocha, M. (2016). Examination of the addictive and behavioral properties of fatty acid-binding protein inhibitor SBFI26. Front Psychiatry, 7, 54.
PMID: 27092087 PMCID: PMC4820685 DOI: 10.3389/fpsyt.2016.00054

Thanos, P.K., Hamilton, J., O'Rourke, J.R., Napoli, A., Febo, M., Volkow, N.D., Blum, K., & Gold, M. (2016). Dopamine D2 gene expression interacts with environmental enrichment to impact lifespan and behavior. Oncotarget, 7(15), 19111-23.
PMID: 26992232 PMCID: PMC4991369 DOI: 10.18632/oncotarget.8088

Thanos, P.K., Malave, L., Delis, F., Mangine, P., Kane, K., Grunseich, A., Vitale, M., Greengard, P., & Volkow, N.D. (2016). Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned place preference in male but not in female mice. Synapse, 70(7), 293-301.
PMID: 26990537 DOI: 10.1002/syn.21904

Thanos, P. K., Restif, C., O'Rourke, J. R., Lam, C. Y., & Metaxas, D. (2015). Mouse Social Interaction Test (MoST): a quantitative computer automated analysis of behavior. Journal of Neural Transmission, [Epud ahead of print]
PMID: 26704381 | DOI: 10.1007/s00702-015-1487-0 

Kaczocha ,M., Glaser, S. T., Maher, T., Clavin, B., Hamilton, J., O'Rourke, J., Rebecchi, M., Puopolo, M., Owada, Y., & Thanos, P. K. (2015). Fatty acid binding protein deletion suppresses inflammatory pain through endocannabinoid/N-acylethanolamine-dependent mechanisms. Molecular Pain11, 52.
PMID: 26311517 | PMCID: PMC4551694 | DOI: 10.1186/s12990-015-0056-8

Thanos, P. K., Michaelides, M., Subrize, M., Miller, M. L., Bellezza, R., Cooney, R. N., Leggio, L., Wang, G. J., Rogers, A. M., Volkow, N. D., & Hajnal, A. (2015). Roux-en-Y Gastric Bypass Alters Brain Activity in Regions that Underlie Reward and Taste Perception. PLOS ONE10, e0125570.
PMID: 26039080 | PMCID: PMC4454506 | DOI: 10.1371/journal.pone.0125570

Delis, F., Rombola, C., Bellezza, R., Rosko, L., Grandy, D. K., Volkow, N. D., & Thanos, P. K. (2015). Regulation of ethanol intake under chronic mild stress: roles of dopamine receptors and transporters. Frontiers in Behavioral Neuroscience9, 118.
PMID: 26029066; PMCID: PMC4428139 | DOI: 10.3389/fnbeh.2015.00118

Blum, K., Thanos, P. K., Badgaiyan, R. D., Febo, M., Oscar-Berman, M., Fratantonio, J., Demotrovics, Z., & Gold, M. S. (2015). Neurogenetics and gene therapy for reward deficiency syndrome: are we going to the Promised Land? Expert Opinion on Biological Therapy, 15, 973-985.
PMID: 25974314 | DOI: 10.1517/14712598.2015.1045871

Thanos, P. K., Roushdy, K., Sarwar, Z., Rice, O., Ashby, C. R., Jr., & Grandy, D. K. (2015). The effect of dopamine D4 receptor density on novelty seeking, activity, social interaction, and alcohol binge drinking in adult mice. Synapse69, 356-364.
PMID: 25914336 | DOI: 10.1002/syn.21822

Volkow, N. D., Wang, G. J., Logan, J., Alexoff, D., Fowler, J. S., Thanos, P. K., Wong, C., Casado, V., Ferre, S., & Tomasi, D. (2015). Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain. Translational Psychiatry5:e549.
PMID: 25871974 | PMCID: PMC4462609 | DOI: 10.1038/tp.2015.46.

Blum, K., Febo, M., Thanos, P. K., Baron, D., Fratantonio, J., & Gold, M. (2015). Clinically Combating Reward Deficiency Syndrome (RDS) with Dopamine Agonist Therapy as a Paradigm Shift: Dopamine for Dinner? Molecular Neurobiology, [Epub ahead of print]
PMID: 25750061

Thanos, P. K., Robison, L. S., Steier, J., Hwang, Y. F., Cooper, T., Swanson, J. M., Komatsu, D. E., Hadjiargyrou, M., & Volkow, N. D. (2015). A pharmacokinetic model of oral methylphenidate in the rat and effects on behavior. Pharmacology Biochemistry and Behavior, 131, 143-153.
PMID: 25641666 | DOI: 10.1016/j.pbb.2015.01.005

Roux, A., Muller, L., Jackson, S. N., Baldwin, K., Womack, V., Pagiazitis, J. G., O'Rourke, J. R., Thanos, P. K., Balaban, C., Schultz, J. A., Volkow, N. D., & Woods, A. S. (2015). Chronic ethanol consumption profoundly alters regional brain ceramide and sphingomyelin content in rodents. ACS Chemical Neuroscience6, 247-259.
PMID: 25387107 | PMCID: PMC4372063 | DOI: 10.1021/cn500174c

Blum, K., Thanos, P. K., & Gold, M. S. (2014). Dopamine and glucose, obesity and reward deficiency syndrome. Frontiers in Psychology5, 919.
PMID: 25278909 | PMCID: PMC4166230 | DOI: 10.3389/fpsyg.2014.00919

Thanos, P. K., Delis, F., Rosko, L., & Volkow, N. D. (2013). Passive Response to Stress in Adolescent Female and Adult Male Mice after Intermittent Nicotine Exposure in Adolescence. Journal of Addiction Research & TherapyS6, 007.
PMID: 24619539 | PMCID: PMC3947500 DOI: 10.4172/2155-6105.S6-007

Polston, J. E., Pritchett, C. E., Tomasko, J. M., Rogers, A. M., Leggio, L., Thanos, P. K., Volkow, N. D., & Hajnal, A. (2013). Roux-en-Y gastric bypass increases intravenous ethanol self-administration in dietary obese rats. PLOS ONE8, e83741.
PMID: 24391816 | PMCID: PMC3877092 | DOI: 10.1371/journal.pone.0083741

Hajnal, A., Thanos, P. K., & Volkow, N. D. (2013). Notes on "roux en y gastric bypass increases ethanol intake in the rat" by Davis et al. Obesity Surgery23, 1317.
PMID: 23649870 | PMCID: PMC3702640 | DOI: 10.1007/s11695-013-0961-8

Grady, D. L., Thanos, P. K., Corrada, M. M., Barnett, J. C., Jr., Ciobanu, V., Shustarovich, D., Napoli, A., Moyzis, A. G., Grandy, D., Rubinstein, M., Wang, G. J., Kawas, C. H., Chen, C., Dong, Q., Wang, E., Volkow, N. D., & Moyzis, R. K. (2013). DRD4 Genotype Predicts Longevity in Mouse and Human.  The Journal of Neuroscience33, 286-291.
PMID: 23283341 | PMCID: PMC3710129 | DOI: 10.1523/JNEUROSCI.3515-12.2013

Michaelides, M., Anderson, S. A., Ananth, M., Smirnov, D., Thanos, P. K., Neumaier, J. F., Wang, G. J., Volkow, N. D., & Hurd, Y. L.. (2013). Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks. The Journal of Clinical Investigation123, 5342-5350.
PMID: 24231358 | PMCID: PMC3859392 | DOI: 10.1172/JCI72117