Fatty Acid Binding Protein – Mediated Control of Endocannabinoid Signaling and Drug Addiction

Thanos  | Haj-Dahmane
This translational study will look at the role of fatty acid binding proteins in the brain’s endocannabinoid system, particularly in the mechanisms controlling reward and addiction, to identify new potential targets for drug therapies to fight addiction.

Results from preclinical studies have established that endocannabinoids (eCBs) play a pivotal role in controlling reward-related behaviors and that dysregulated eCB signaling contributes to the development and persistence of addictive behaviors. Following recent studies by the researchers which have begun to unravel the mechanism of eCB transport at central synapses, this study will use a multidisciplinary approach to test the hypothesis that fatty acid binding proteins (FABPs) control retrograde eCB signaling. It also will delineate the precise role of FABPs in eCB signaling and function of the brain’s reward circuit and addiction-related behaviors. The ultimate objective of this application is to enhance the understanding of the eCB signaling and its role in controlling addiction-related behaviors, a necessary step toward the development of improved treatment strategies for addiction.

Principal Investigators
Panayotis (Peter) K. Thanos, PhD

Research Institute on Addictions

Samir Haj-Dahmane, PhD
Research Institute on Addictions

Funding Agency
National Institute on Drug Abuse (NIDA)

Grant Number
R21- DA045863

Dates
2018-2020