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Alan D. Hutson PhD

Chair & Professor

Specialty/Research Focus



Education and Training:
  • PhD, Statistics, University of Rochester (1996)
  • MA, Statistics, University of Rochester (1993)
  • MA, Statistics, State University of New York at Buffalo (1990)
  • BA, Statistics, State University of New York at Buffalo (1988)
  • AMT, University of New Hampshire (1985)
  • Chief, Division of Biostatistics and Associate Professor, Social and Preventive Medicine, State University of New York at Buffalo (2002-present)
  • Associate Professor, Statistics, University of Florida (2002)
  • Assistant Professor, Statistics, University of Florida (2001–2002)
  • Associate Director, Division of Biostatistics, University of Florida (2001–2002)
  • Director, University of Florida, Center for Biostatistics & Epidemiology (2000–2002)
  • Director of the Biostatistics Coordinating Center for the DCA-MELAS phase III clinical trial, Statistics, University of Florida (1999–2002)
  • Director of the Biostatistics Coordinating Center for the DCA-CLA phase III clinical trial, Statistics, University of Florida (1996–2002)
  • Director of the GCRC Informatics Core, Statistics, University of Florida (1996–2002)
  • Interim Director, Division of Biostatistics, University of Florida (2000–2001)
  • Research Assistant Professor, Statistics, University of Florida (1996–2001)
  • Director of the Biostatistics Coordinating Center for the DCA-MALA phase III clinical trial, Statistics, University of Florida (1996–1999)
  • Research Trainee, Department of Biostatistics, University of Rochester (1992–1996)
  • Instructor, Statistics, University of Rochester (1994–1995)
  • Teaching Assistant, Statistics, University of Rochester (1991–1992)
  • Biostatistician, Otsuka America Pharmaceuticals, Inc. (1990–1991)
  • Teaching Assistant, Statistics, State University of New York at Buffalo (1988–1990)
  • Research Apprentice in the Biomathematics Department, Roswell Park Cancer Institute (1989)
See all (7 more)
Awards and Honors:
  • Bonus Pay Award (1999)
  • Awarded UF CLAS Research Initiation Project (1997)
  • Environmental Health Sciences Training Grant (4 years)
  • Various tuition scholarships, Regents scholarship
  • Scholar Athlete (SUNY Buffalo)

Research Expertise:
  • Computer Skills: Operating Systems: UNIX, VMS, CMS, DOS and macintosh. Software: SAS, IMSL(Fortran), Mathematica, MINITAB, JMP, Microsoft Word, LaTex, CART, STPLAN, StatXact, nQuery, and Harvard Graphics.
Grants and Sponsored Research:
  • January 2016–January 2020
    Clinical Translational Science Award (CTSA)
    National Institutes of Health
    Role: Co-Investigator

Journal Articles:
  • Chevuru SC, Sola MC, Theriaque DW, Hutson AD, Leung WC, Perez JA, Nelson RM, Kays DW, Christensen RD. Multicenter analysis of platelet transfusion usage among neonates on extracorporeal membrane oxygenation.. Pediatrics. 2002; 109(6).
  • Robles LD, Frost AR, Davila M, Hutson AD, Grizzle WE, Chakrabarti R. Down regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer.. J Biol Chem. 2002.
  • Sullivan SE, Staba SL, Gersting JA, Hutson AD, Theriaque D, Christensen RD, Calhoun DA. Circulating concentrations of chemokines in cord blood, neonates, and adults.. Pediatr Res. 2002; 51(5).
  • Garcia MG, Hutson AD, Christensen RD. Effect of recombinant erythropoietin on 'late' transfusions in the neonatal intensive care unit: a meta-analysis.. J Perinatol. 2002; 22(2).
  • Neiberger RE, George JC, Perkins LA, Theriaque DW, Hutson AD, Stacpoole PW. Renal manifestations of congenital lactic acidosis.. Am J Kidney Dis. 2002; 39(1).
  • Sherman J, Patel P, Hutson A, Chesrown S, Hendeles L. Adherence to oral montelukast and inhaled fluticasone in children with persistent asthma.. Pharmacotherapy. 2001; 21(12).
  • Lossie AC, Whitney MM, Amidon D, Dong HJ, Chen P, Theriaque D, Hutson A, Nicholls RD, Zori RT, Williams CA, Driscoll DJ. Distinct phenotypes distinguish the molecular classes of Angelman syndrome.. J Med Genet. 2001; 38(12).
  • Sola MC, del Vecchio A, Edwards TJ, Suttner D, Hutson AD, Christensen RD. The relationship between hematocrit and bleeding time in very low birth weight infants during the first week of life.. J Perinatol. 2001; 21(6).
  • Hutson AD. Bootstrap-type confidence intervals for quantiles of the survival distribution.. Stat Med. 2001; 20(11).
  • Del Vecchio A, Sola MC, Theriaque DW, Hutson AD, Kao KJ, Wright D, Garcia MG, Pollock BH, Christensen RD. Platelet transfusions in the neonatal intensive care unit:factors predicting which patients will require multiple transfusions.. Transfusion. 2001; 41(6).
  • Perez EE, Rose SL, Peyser B, Lamers SL, Burkhardt B, Dunn BM, Hutson AD, Sleasman JW, Goodenow MM. Human immunodeficiency virus type 1 protease genotype predicts immune and viral responses to combination therapy with protease inhibitors (PIs) in PI-naive patients.. J Infect Dis. 2001; 183(4).
  • Juul SE, Zhao Y, Dame JB, Du Y, Hutson AD, Christensen RD. Origin and fate of erythropoietin in human milk.. Pediatr Res. 2000; 48(5).
  • Kauwell GP, Wilsky CE, Cerda JJ, Herrlinger-Garcia K, Hutson AD, Theriaque DW, Boddie A, Rampersaud GC, Bailey LB. Methylenetetrahydrofolate reductase mutation (677C-->T) negatively influences plasma homocysteine response to marginal folate intake in elderly women.. Metabolism. 2000; 49(11).
  • Sola MC, Du Y, Hutson AD, Christensen RD. Dose-response relationship of megakaryocyte progenitors from the bone marrow of thrombocytopenic and non-thrombocytopenic neonates to recombinant thrombopoietin.. Br J Haematol. 2000; 110(2).
  • Sherman J, Hutson A, Baumstein S, Hendeles L. Telephoning the patient's pharmacy to assess adherence with asthma medications by measuring refill rate for prescriptions.. J Pediatr. 2000; 136(4).
  • Sola MC, Christensen RD, Hutson AD, Tarantal AF. Pharmacokinetics, pharmacodynamics, and safety of administering pegylated recombinant megakaryocyte growth and development factor to newborn rhesus monkeys.. Pediatr Res. 2000; 47(2).
  • Calhoun DA, Lunøe M, Du Y, Hutson AD, Veerman M, Christensen RD. Granulocyte colony-stimulating factor serum and urine concentrations in neutropenic neonates before and after intravenous administration of recombinant granulocyte colony-stimulating factor.. Pediatrics. 2000; 105(2).
  • Baggs JG, Schmitt MH, Mushlin AI, Mitchell PH, Eldredge DH, Oakes D, Hutson AD. Association between nurse-physician collaboration and patient outcomes in three intensive care units.. Crit Care Med. 1999; 27(9).
  • Müller S, Hutson A, Arya V, Hochhaus G. Assessment of complex peptide degradation pathways via structured multicompartmental modeling approaches: the metabolism of dynorphin A1-13 and related fragments in human plasma.. J Pharm Sci. 1999; 88(9).
  • Litherland SA, Xie XT, Hutson AD, Wasserfall C, Whittaker DS, She JX, Hofig A, Dennis MA, Fuller K, Cook R, Schatz D, Moldawer LL, Clare-Salzler MJ. Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus.. J Clin Invest. 1999; 104(4).
  • Sola MC, Calhoun DA, Hutson AD, Christensen RD. Plasma thrombopoietin concentrations in thrombocytopenic and non-thrombocytopenic patients in a neonatal intensive care unit.. Br J Haematol. 1999; 104(1).
  • Stacpoole PW, Bunch ST, Neiberger RE, Perkins LA, Quisling R, Hutson AD, Greer M. The importance of cerebrospinal fluid lactate in the evaluation of congenital lactic acidosis.. J Pediatr. 1999; 134(1).
  • Geiser EA, Wilson DC, Wang DX, Conetta DA, Murphy JD, Hutson AD. Autonomous epicardial and endocardial boundary detection in echocardiographic short-axis images.. J Am Soc Echocardiogr. 1998; 11(4).
  • Baggs JG, Schmitt MH, Mushlin AI, Eldredge DH, Oakes D, Hutson AD. Nurse-physician collaboration and satisfaction with the decision-making process in three critical care units.. Am J Crit Care. 1997; 6(5).
  • Katz PR, Karuza J, Kolassa J, Hutson A. Medical practice with nursing home residents: results from the National Physician Professional Activities Census.. J Am Geriatr Soc. 1997; 45(8).
  • Phelps CE, Hutson A. Estimating diagnostic test accuracy using a 'fuzzy gold standard'.. Med Decis Making. ; 15(1).
  • Mudholkar, G.S., Alan Hutson. Hermitian Quantile Curves as Statistical Plots. Communications in Statistics-Simulations and Computation. ; 27.
  • Alan Hutson, Wilson, D.C., Geiser, E.A.. Measuring Relative Agreement: Echocardiographer Versus Computer. Journal of Agricultural, Biological, and Environmental Statistics. ; 3.
  • Mudholkar, G.S., Alan Hutson. Improvements in the Bias and Precision of Sample Quantiles. Statistics. ; 30.
  • Mudholkar, G.S., Alan Hutson. Continuity Corrected Approximations for and "Exact" Inference with Pearson's X. Journal of Statistical Planning and Inference. ; 59.
  • Satoh M, Behney KM, Mizutani A, Richards HB, Hutson AD, Reeves WH. Titration emulation: a computer-assisted technique that simplifies the quantification of anti-dsDNA antibodies using the Crithidia luciliae assay.. Lupus. ; 10(9).
  • Garcia MG, Duenas E, Sola MC, Hutson AD, Theriaque D, Christensen RD. Epidemiologic and outcome studies of patients who received platelet transfusions in the neonatal intensive care unit.. J Perinatol. ; 21(7).
  • Mudholkar, G.S., Freimer, M., Alan Hutson. On the Efficiencies of Some Common Quick Estimators. Communications in Statistics-Theory and Methods. ; 26.
  • Mudholkar, G.S., Alan Hutson. Some Refinements of the Quasi-Quantiles. Statistics and Probability Letters. ; 32.
  • Mudholkar, G.S., Alan Hutson. Asymmetric Quasimedians: Remarks on an Anomaly. Statistics and Probability Letters. ; 32.
  • Alan Hutson. "Exact" Bootstrap Confidence Bands for the Quantile Function via Steck's Determinant. Journal of Computational and Graphical Statistics. ; 11.
  • Alan Hutson. Quasi Medians are Robust and Relatively Efficient Estimators of a Common Mean Given Multivariate Normality. Statistics & Probability Letters..
  • Alan Hutson. Analytical Bootstrap Methods for Censored Data. Journal of Applied Mathematics and Decision Science. ; 6.
  • Alan Hutson, Fishbein, L., O'Brien, P., Stacpoole, P.W.. Accounting for Plasma Levels Below Detection LImits in a One-Compartment Zero-Order Absorption Pharmacokinetics Model. Journal of Applied Statistics..
  • Alan Hutson. A Semiparametric bootstrap approach to correlated data analysis problems. Computer Methods and Programs in Biomedicine..
  • Mudholkar, G.S., Alan Hutson, Marchetti, C.E.. A Simple Hermitian Estimator of the Quantile Function. Journal of Nonparametric Statistics. ; 13.
  • Alan Hutson. A Semiparametric Quantile Function Estimator for use in Bootstrap Estimation Procedures. Statistics and Computing..
  • Alan Hutson. Rational Spline Estimators of the Quantile Function. Communications and Statistics-Simulation and Computation. ; 30.
  • Alan Hutson. A Composite Quantile Function Estimator with Applications in Bootstrapping. Journal of Applied Statistics. ; 27.
  • Alan Hutson. Estimating the Covariance of Bivariate Order Statistics with Applications. Statistics & Probability Letters. ; 48.
  • Mudholkar, G.S., Alan Hutson. The Epsilon-Skew-Normal Distribution for Analyzing Near-Normal Data. Journal of Statistical Planning and Inference. ; 83.
  • Alan Hutson. Calculating Nonparametric Confidence Intervals for Quantiles Using Fractional Order Statistics. Journal of Applied Statistics. ; 26.
  • Alan Hutson. Direct Estimation of the Percentile "p-value" for the One-Sample Median Test. Journal of Applied Statistics. ; 25.
  • Mudholkar, G.S., Alan Hutson. LQ-moments: Analogs of L-moments. Journal of Statistical Planning and Inference. ; 71.
See all (39 more)
  • Alan Hutson, Ernst, M.D.. The Exact Bootstrap Mean and Variance of an L-estimator. Journal of the Royal Statistical Society-Series B. ; 62.
Evaluative Studies and Case Reports:
  • Duncan GE, Hutson AD, Stacpoole PW. QUICKI is not a useful and accurate index of insulin sensitivity following exercise training.. J Clin Endocrinol Metab. 2002; 87(2).
  • Stacpoole PW, Fisher WR, Flotte TR, Geiser EA, Theriaque DW, Hutson AD. Teaching hypothesis-oriented thinking to medical students: the University of Florida's clinical investigation program.. Acad Med. 2001; 76(3).

Professional Memberships:
  • Member ASA, IMS, Association of GCRC Statisticians, Society for Controlled Clinical Trials
  • President-elect 01-02 for the Association of GCRC Statisticians

School News:
In the Media:

Clinical Specialties:
Clinical Offices:
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Contact Information

Department of Biostatistics
705 Kimball Tower
Buffalo, NY 14214
Phone: 716-829-2594
Fax: 716-829-2200

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