Dr. Hu has been with the Center for Computational Research since 2002. He works with users interested in bioinformatics resources and provides support and assistance to UB faculty and Roswell Park researchers.
Bioinformatics and computational biology support include the
development of customized tools and approaches to support faculty
led research and advanced data analysis and mining for research
projects and funding application, those include:
I am currently pursuing a variety of computational and genomics topics and collaborating with colleagues on large-scale genomics projects, including developing statistical and computational approaches for gene expression, transcriptional regulatory network, and large-scale sequence analyses. My independent research interest is on the global gene regulation at both transcriptional and post-transcriptional levels. The major focus is to use computational approaches to integrate high-throughput biological data to ask questions and understand gene regulation mechanisms in a systems level. These include:
Transcriptional Regulation of Gene expression. Regulation of gene expression plays a key role in many cellular processes, including proliferation, senescence and development. Transcription is a major target for regulation of gene expression in all organisms, and failure to correctly regulate transcription is a cause of many diseases, notably cancer. Indeed, many human oncogenes are themselves transcriptional regulators. Transcriptional regulation also plays a key role in the virulence of many human pathogens. Therefore it is vital to understand the mechanisms by which transcription is regulated. My research is focused on the mechanisms of transcriptional regulation of disease-related gene expression;My research also includes conducting genome-wide studies of regulatory elements to elucidate the regulatory logic of transcription factors and their corresponding binding sites in controlling gene expression and applying the developed statistical and computational approaches from the above research to collaborative projects.
Post-transcriptional Gene Regulation by microRNAs. microRNAs will shape biology and change the traditional concepts of the molecular biology. My research focus is to uncover the widespread influence of miRNAs on disease-related gene expression.
Genetic Variation and Diseases. Genetic variations play important roles in the regulation of gene expression such as miRNA and SNPs. We are interested in addressing the questions as how different miRNAs and SNPs might contribute separately or synergistically to specific phenotypes such as diseases.
1R01AI08556901A2 Schwartz (PI) - 09/2009 - 08/2011
Integration of Clinical, Genomic and Proteomic Data In HIV-1 using a Bioinformatic Approach
The overall goal of this study is the integration of the clinical, genomic and proteomic data derived from unique HIV-1 patient cohorts using bioinformaticsto yield a comprehensive database from which to predict patient outcomes and responses to therapy.
5R01AI028304-20 Murphy (PI) - 01/2005 -
Development of a Vaccine for Moraxella Catarrhalis
The overall goal of this proposal is to evaluate proteins as vaccine antigens and to use a powerful genomics approach to identify and study potential vaccine antigens for M. catarrhalis.
American Heart Association - Yu (PI) - 01/2008 -
The Role of Protein Arginine Methlation in Gene Expression
5R01DK074867-04 - Collins (PI) - 07/2007 -
Molecular Mechanisms of Intestinal Metal Ion Transport During Iron-Deficiency
The overall goals are to determine the roles that Dmti and Atpya play in the induction of copper transport during iron-deprivation and to decipher the molecular mechanisms of induction of Dmti and Atpya during iron-deprivation.
5R01NS061856-02 - Feng (PI) - 12/2008 - 12/2013
Cellular Functions of Parkin
The overall goal is to improve our understanding of parkin and genes linked to early-onset Parkinson's disease, and to provide novel targets for the development of more effective therapies for Parkinson's disease.
Spring 2010 - Instructor for "Introduction of Bioinformatics and Computational Biology" BCH519 for graduate students
Spring 2009 - Instructor for "Introduction of Bioinformatics and Computational Biology" BCH519 for graduate students
Spring 2008 - Instructor for "Introduction of Bioinformatics and Computational Biology" BCH519 for graduate students
Spring 2007 - Instructor for "Introduction of Bioinformatics and Computational Biology" BCH519 for graduate studentS
SUNY at Buffalo
701 Ellicott Street
Buffalo, New York, 14203
Other UB Positions:
Dept. of Ophthalmology
Adjunct Assistant Professor
Dept. of Biostatistics
Research Assistant Professor
Dept. of Medicine