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Michael                        Buck

Michael Buck PhD

Department of Biochemistry

Associate Professor

Specialty/Research Focus

Bioinformatics; Gene Expression; Genomics and proteomics; Molecular and Cellular Biology; Molecular genetics; Transcription and Translation

Professional Summary:

Our research group is interested in how regulatory proteins are targeted to the correct DNA binding sites at the correct time. Transcription factors are directed to their genomic targets by DNA sequence, local chromatin structure, and protein-protein interactions. These modulators of transcription factor binding are not independent but function both cooperatively and competitively to regulate where transcription factors bind. Understanding how these modulators affect transcription factor binding in vivo remains a major unsolved biological problem.

We use the model organism Saccharomyces cerevisiae to address the disconnect between the presence of the correct DNA binding sequence and true regulatory protein binding, integrating both experimental and computational approaches to: i) investigate transcription factor binding in response to environmental stress, ii) identify and characterize the mechanisms directing transcription factor target selection, and iii) and develop bioinformatics tools to analyze and interpret ChIP-seq experiments and chromatin structural patterns.

Education and Training:
  • PhD, Genetics, North Carolina State University (2003)
  • BS, Biotechnology, Rutgers University, Cum Laude (1997)
  • Director, Stem Cell Sequencing/Epigenomics Center, The State University of New York at Buffalo (2011-present)
  • Co-Director, Next-Generation Sequencing & Expression Analysis Core, The State University of New York at Buffalo (2010-present)
  • Member, Cellular and Molecular Biology Graduate Program, Roswell Park Cancer Institute (2008-present)
  • Member, The State University of New York at Buffalo, Center of Excellence in Bioinformatics and Life Sciences (2007-present)
  • Assistant Professor, Biochemistry, The State University of New York at Buffalo (2007-present)
  • Postdoctoral Fellow, Biology, University of North Carolina at Chapel Hill (2003–2007)

UB 2020 Strategic Strengths:
  • Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
  • August 2011–July 2015
    Western New York Stem Cell Culture and Analysis Center
    Role: Co-Investigator
  • August 2010–July 2013
    Overlapping Clustering Analysis of Biological Networks
    Role: Co-Principal Investigator
  • Epi)Genomic drivers of primary and metastatic pancreatic islet cell carcinoma
    National Institutes of Health
    Role: Co-Investigator

Journal Articles:
See all (24 more)

School News:
In the Media:

Clinical Specialties:
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Contact Information

701 Ellicott St
Center Of Excellence in Bioinformatics
Room B3-304
Buffalo, NY 14203
Phone: (716) 881-7569

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